Prolymphocyte



 

Morphology 

 

Sizeİ: 15µm
Shape round
Nucleus round
Chromatin intermediate, very slightly condensed
Nucleolusİ: 1 clearly visible
Nuclear/Cytoplasmic Ratio (N/C)=0.6 with a lightly basophilic colour
Granulesİ: None

The prolymphocyte is seen pathologically in lymph node sections or on the blood and bone marrow films of patients with chronic lymphocytic leukaemia which is undergoing transformation towards a prolymphocytic leukaemia. In this situation the calculation of the percentage of prolymphocytes is crucial to the diagnosis.


Note

It should be remembered that in these pathological areas an important feature is a hyperlymphocytosis, by definition greater than 4 x109/L.